Ethier, removed from Thursday's game in Milwaukee because the toe pain hampered his running, said the toe was cut from the pressure of an ingrown toenail against the shoe and the cut became infected.
A portion of his toenail was removed Friday and he said the area was still numb from an injection.
Manager Don Mattingly, who started Juan Rivera in right field and batted Aaron Miles third, said there was a chance Ethier could have started Friday night and he expected Ethier to be available later in the game for pinch-hitting or defense.
"I don't think it will be more than a day," Mattingly said. "I didn't want to wait until game time to make a decision. They said it limited him a little running, starting and stopping."
Mattingly said the toe problem surfaced recently.
Ethier is 8-for-22 lifetime against Jason Hammel, who started for the Rockies on Friday night.