The only scoring of the game to that point was a solo home run off Lowe by Astros catcher Eric Munson in the third inning.
The top of the fifth inning ended when Lowe was thrown out at first base by Astros right fielder Luke Scott, who fielded Lowe's soft one-hopper and fired to first baseman Lance Berkman ahead of Lowe, who hit the bag awkwardly and jogged well past first base.
Lowe allowed a single to Jason Lane leading off the bottom of the fifth and that brought manager Grady Little and trainer Stan Johnston out of the dugout. After a brief discussion, Lowe left the field and slammed his glove against the dugout wall as he disappeared toward the clubhouse.
Jeff Kent tied the game in the top of the seventh inning with a solo home run, but Carlos Lee's solo homer in the bottom of the seventh put Houston back in front.
Ken Gurnick is a reporter for MLB.com This story was not subject to the approval of Major League Baseball or its clubs.