In the final game for both teams before the start of the regular season, the Dodgers' Andre Ethier hit an RBI double and James Loney hit a two-run bloop single in the first, giving the team an early 3-0 lead.
Tacking on two more runs against Mariners starter Erik Bedard, Matt Kemp had an RBI single in the third inning and Marcus Thames hit a solo home run to begin the fourth, his first homer of the spring.
2010 Spring Training - null
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Bedard, who came into Wednesday's game with a 3-0 record and 1.13 ERA, gave up five runs on seven hits in four innings. The Mariners lefty had only given up a total of two runs in five earlier starts.
Getting his third start of the spring, De La Rosa gave up only two hits, while striking out six. Three of his strikeouts came in the second inning, when De La Rosa struck out all three Mariners hitters he faced.
Corey Smith, who replaced Loney at first base in the fourth inning and came into Wednesday's game batting .600 (6-for-10) with six RBIs, belted a three-run home run into the Dodgers' bullpen in the fifth inning.
The lone Mariners run came in the eighth, when Michael Saunders belted a home run off Dodgers reliever Steven Ames.
With the win, the Dodgers finished the spring 14-21-1, while the Mariners ended with a 16-13-2 record.
Up next for Mariners: Seattle will square off Friday against the A's in Oakland for Opening Day, with the first pitch set for 7:07 p.m. PT. The Mariners will send Felix Hernandez to the mound for his fourth career Opening Day start, third in a row, against the A's Trevor Cahill. In three games this spring, Hernandez pitched 11 2/3 innings, going 1-1 with a 4.63 ERA and 15 strikeouts.
Up next for Dodgers: To begin the 2011 regular season, the Dodgers will face off Thursday against the Giants at Dodger Stadium, with the first pitch set for 5 p.m. PT. It will mark the 10th time in Los Angeles Dodgers history that the club will open the season against the Giants, and the seventh at Dodger Stadium. Clayton Kershaw will get the start for the Dodgers against Giants right-hander Tim Lincecum. This spring, Kershaw went 2-1 with a 2.49 ERA, while striking out 20 in 25 1/3 innings pitched.
Quinn Roberts is a contributor for MLB.com This story was not subject to the approval of Major League Baseball or its clubs.